Aarvik MUTTA™ ADC Platform
Advancing the Future in ADCs
Aarvik MUTTA™ ADC Platform
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Target
Antibody
Payload
Linker
Conjugation
Expression-based
screening for
target pairs
Combined copy
number across
targets
Improved
internalization
Multitarget /
Multivalent (up
to 4)
Readily
manufacturable
Multiple formats
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Modular
With or without
common light
chain
Function
blocking (where
feasible)
Binder
architecture
Novel or existing
CDRs
Proprietary
payloads
Diversified
payloads
Payload
matching
Proprietary
hydrophilic
cleavable linkers
Site-specific
conjugation
Monospecific ADCs
Demonstrate limited target dependent potency, especially on heterogeneously expressed solid tumors
Bispecific MUTTA™ ADCs
- Apply OR-gate approach to kill single or dual antigen-expressing tumor cells
- Overcome antigen escape limitation seen with monospecific ADCs
